New Functional Imaging Technology to Differentiate between Chronic Obstructive Pulmonary Disease and Heart Failure

We are investigating the potential role for vibration response imaging (VRI) in the prompt emergency department (ED) evaluation of patients presenting with dyspnea to aid in differentiation between chronic obstructive pulmonary disease (COPD) and heart failure (HF). VRI is a noninvasive, bedside computer-based technology that creates a visually dynamic two-dimensional image of distribution of vibration within the lungs during the respiratory process. The acoustic signals, recorded from 36 posteriorly positioned surface skin auditory sensors, are transferred to a hardware board where several stages of filtering are applied to select a specific frequency band. The filtered output signal frequencies are presented as a gray-scale coded dynamic image consisting of a series of 0.17 s frames and as a table featuring the percentage contribution of each lung and lung sector (upper, middle, lower) to the total vibration signal. Darker images represent more prominent airway vibration, but do not necessarily differentiate laminar from turbulent flow. These images and calculations may be useful in delineating HF from other lung disease in acutely dyspneic patients.1 The patient whose image is presented here is a 55-yearold male who presented with shortness of breath and bilateral lower extremity edema. Vital signs at triage were pulse of 88 beats per minute, blood pressure of 160/108 mmHg and respiratory rate of 18 breaths per minute. He gave no history of respiratory or cardiac disease but was a long-time heavy tobacco smoker; his portable chest radiograph was unremarkable. Serum brain natriuretic peptide (BNP) was 136 pg/ml. At the bedside, the emergency physician obtained a VRI (Figure). VRI clearly showed bibasilar diminution both in the image (note the darker intensity as well as broader area in the upper lungs) and as quantified in the table. This pattern in VRI is typical for an acute HF presentation. Bedside transthoracic echocardiography revealed an estimated left ventricular ejection fraction of only 35%. The patient was given intravenous diuretic and nitroglycerin therapy resulting in Figure. Components of vibration response imaging include visual and quantitative phonographic characterization of the lungs. In this patient there is bibasilar diminution both in the image (note the darker intensity as well as broader area in the upper lungs) and as quantified in the table. Calculated for frames from 1 to 71